To the authors's knowledge the effect of high dose therapy with cyclophosphamide during childhood on adult testicular reproductive and endocrine function has not been established. METHODS: Gonadal function was studied in 17 adult male survivors of childhood sarcomas treated with high dose pulse cyclophosphamide therapy as part of a VAC vincristine, actinomycin, and cyclophosphamide or Adria-VAC doxorubicin, vincristine, actinomycin, and cyclophosphamide chemotherapy regimen. Patients answered a questionnaire concerning sexual functioning and underwent a comprehensive physical examination, semen analysis, and hormonal evaluation.
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Chemotherapyradiation therapyand other treatments can be very effective at doing their job. But what makes them good at fighting cancer or other illnesses also can cause side effects : As these treatments attack harmful cells, they may affect some healthy cells too. Your doctor has probably talked about whether you'll have any side effects from your cancer treatment.
Howell, S. Treatment with cytotoxic chemotherapy and radiotherapy is associated with significant gonadal damage in men, and alkylating agents are the most common agents implicated. The vast majority of men receiving procarbazine-containing regimens for the treatment of lymphomas are rendered permanently infertile, whereas treatment with doxorubicin hydrochloride Adriamycinbleomycin, vinblastine, and dacarbazine appears to have a significant advantage, with a return to normal fertility in the vast majority of patients.
Some men are not able to have children due to the effects of cancer treatment. By identifying your risk for infertility, you can take steps before treatment to preserve your fertility. There are options for survivors who experience infertility as a result of cancer or treatment.
Forgot Password? The effects of children's cancer therapy on female reproductive function depend on many factors, including the person's age at the time of cancer therapy, the specific type and location of the cancer, and the treatment that was given. It is important to understand how the ovaries and female reproductive organs function and how they may be affected by therapy given to treat cancer during childhood.
Prepubertal patients receiving chemotherapy are relatively resistant to cyclophosphamide-induced germinal cell alterations. To study the possible protective effect of testosterone used to inhibit germinal cell activity in men who are receiving cyclophosphamide. Five patients received daily oral cyclophosphamide, five received cyclophosphamide in monthly bolus injections, and five received monthly intravenous boluses of cyclophosphamide plus testosterone mg intramuscularly every 15 days.
A lot of things must take place for a couple to make a baby. Here are some things that can happen:. Cancer, or more often cancer treatments, can interfere with some parts of the reproductive process and affect your ability to have children.
Vasculitis activity and its therapy are potential threats to the fertility of patients with vasculitis. Loss of fertility is an important consequence of the disease, but the risks of this occurring can be considerably reduced with newer forms of treatment. As a chronic disease, vasculitis also causes psychosexual and relationship problems due to effects on self-esteem and mental well-being.
Cyclophosphamide is part of a class of drugs called immunosuppressants. It suppresses the body's immune response and reduces inflammation in your lungs. Because inflammation is the precursor to fibrosis scarringwe hope cyclophosphamide will prevent the formation of lung fibrosis and allow the inflamed lung to return to normal.